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Bandyopadhyay Lab uses multi-modal network model to improve cancer pharmacogenomics

Source: Cell Systems
November 7, 2018


Webber et al, Cell Systems (2018), https://doi.org/10.1016/j.cels.2018.10.001

Sourav Bandyopadhyay’s lab at UCSF is seeking a strategy to disrupt cancer pathways. Their approach is to identify how biological networks within cancer cells differ from those of normal cells; and develop technological platforms to design precise cancer therapies targeting those differences.

In a recent Cell Systems paper, lab members James Webber and Swati Kaushik describe an approach to compress data from the multi-omic characterization of hundreds of cancers into a small set of pathway-enriched gene modules using their MAGNETIC (modular analysis of gene networks in cancer) platform. These patient-derived modules can then be compared with data from cell lines, which reveal components of the tumor microenvironment that serve as biomarkers for therapeutic responses.

Read the article here

Filed Under: Of Current Interest

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